REPORTING METHODOLOGICAL ISSUES OF THE MENDELIAN RANDOMIZATION STUDIES IN HEALTH AND MEDICAL RESEARCH: A SYSTEMATIC REVIEW

Reporting methodological issues of the mendelian randomization studies in health and medical research: a systematic review

Abstract Background Mendelian randomization (MR) studies using Genetic risk scores (GRS) as an instrumental variable (IV) have increasingly been used to control for unmeasured confounding in observational healthcare databases.However, proper reporting of methodological issues is sparse in these studies.We aimed to review published papers related to

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Hematopoietic Stem Cell Transplantation for the Treatment of Epstein-Barr Virus-Associated T- or NK-Cell Lymphoproliferative Diseases and Associated Disorders

Chronic active Epstein-Barr virus infection (CAEBV) is opi all about the bows a prototype of EBV-associated T- and/or NK-cell (EBV+ T/NK-cell) lymphoproliferative disorders.Most subtypes of these are lethal.We established a unified treatment strategy composed of step 1 (immunochemotherapy: steroids, cyclosporine A, and etoposide), step 2 (multi-dru

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Tailored anticoagulant treatment after a first venous thromboembolism: protocol of the Leiden Thrombosis Recurrence Risk Prevention (L-TRRiP) study - cohort-based randomised controlled trial

Introduction Patients with a first venous thromboembolism (VTE) are at risk of recurrence.Recurrent VTE (rVTE) can be prevented by extended anticoagulant therapy, but this comes at the cost of an increased risk of bleeding.It is still uncertain whether patients with an intermediate recurrence risk or with a high recurrence and high bleeding risk wi

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